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Summary of mouse PK data for bi-AbCap ID2, FcD2 and IR mAb
| Compound | Dose (mg/kg) | Cmax (µg/mL) | AUC (hr×µg/mL) | CL (mL/hr/kg) | T1/2 (hr) |
|---|---|---|---|---|---|
| mouse (n = 3) | |||||
| IR mAb | 30 | 767 | 63669 | 0.5 | 141 |
| FcD2* | 15 | 195 | 4700 | 2.8 | 78 |
| ID2 | 30 | 571 | 19257 | 1.6 | 66 |
Cmax: peak concentration; AUC: the area under concentration - time curve (0-INF); CL: clearance; T½: terminal half-life (144–336 hours).
Done in a separate study.
