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Estimated values of compartmental pharmacokinetic parameters. Abbreviations: F, bio available fraction; ka, absorption rate; V1, central volume of distribution; k10 systemic elimination and k12, k21 distribution rates. Vmax maximum elimination rate; and kM, Michaelis constant
| Parameter | Value (CV%) |
|---|---|
| F (%) | 5.1 (−) |
| ka (day−1) | 1.59 (18) |
| k10 (day−1) | 0.2 (13) |
| V1 (mL) | 2 (13) |
| k12 (day−1) | 0.46 (−) |
| k21 (day−1) | 0.94 (60) |
| Vmax (day−1) | 12.8 (23) |
| kM (μg/mL) | 0.46 (13) |
| a | 0.026 |
| b | 0.15 |
