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Number of differentially hydroxymethylated clusters (DhMRs) detected at a FDR corrected P-value cut-off ≤ 0.05, effect size ≥ |0.02| or |2%| and number of CpG site per cluster ≥ 5 for hESCs exposed to (A) 0.8 μM or (B) 1.5 μM Pb. Exposure to 0.8 μM Pb caused ≥ 2% increase in 5hmC in 36 hMRs and ≤ 2% decrease in 70 hMRs. Exposure to 1.5 μM Pb concentrations caused ≥ 2% increase in 5hmC in 38 hMRs and ≤ 2% decrease in 162 hMRs.
