Table 1.

Differentially hydroxymethylated (5hmC) regions (DhMRs) for representative genes in hESCs exposed to either 0.8 μM Pb or 1.5 μM Pb. These clusters can be used as potential early 5hmC biomarkers of Pb exposure.

Pb exposure (μM)	Gene	CpG Island	Promoter associated	Effect size	Standard error	P-value	FDR	Number of sites per cluster
0.8	ATP5G1	chr17:46969695-46970125	yes	−0.078	0.023	0.000631	0.015042	7
0.8	ATPAF1	chr1:47133674-47134395	yes	0.028	0.004	1.50E-11	3.59E-09	7
0.8	ETHE1	chr19:44031127-44031504	yes	−0.063	0.011	2.21E-08	2.63E-06	6
0.8	HSD17B4	chr5:118788125-118788428	yes	−0.074	0.021	0.000459	0.011862	6
0.8	AGO2	chr8:141646075-141646514	yes	−0.073	0.014	9.40E-08	9.27E-06	5
1.5	CCND1	chr11:69451136-69458596	yes	−0.034	0.010	0.000912	0.013337	11
1.5	NUF2	chr1:163291479-163292021	yes	−0.148	0.043	0.000539	0.009251	5
1.5	RAD51	chr15:40986871-40987772	yes	−0.074	0.025	0.00306	0.031238	6
1.5	GOLPH3	chr5:32173598-32174837	yes	−0.066	0.022	0.003354	0.033245	7
1.5	SOD1	chr21:33031734-33032657	yes	−0.064	0.021	0.002905	0.030225	6