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. 2014 Oct 30;6(5):1265–1273. doi: 10.4161/mabs.29825

Figure 4.

Figure 4.

2095–2 restores in vivo platelet depletion to IdeS-generated F(ab’)2 fragments of c7E3 in canines. Treatment of canines with saline (open black diamonds), 0.05 mg/kg of 2095–2 alone (gray up triangles), and 0.05 mg/kg of IdeS-generated F(ab’)2 fragments of c7E3 alone (solid brown squares) did not result in platelet depletion, whereas treatment with 0.05 mg/kg of intact c7E3 (solid black circles) resulted in platelet depletion. The combined treatment of 0.05 mg/kg of c7E3 F(ab’)2 IdeS and 0.5 mg/kg of 2095–2 (open red circles) resulted in rapid platelet clearance. Data are representative of the average +/− SEM of three animals per group.