Figure 5. Network-based correlation analysis for HCT 116 and HEPA-1 cell models.

Conserved correlation differences between normoxia, hypoxia and anoxia were mapped onto the EHMN reconstruction using a shortest path analysis described previously¹³. Pathways are coloured according to which oxygen levels correlation differences occurred and are presented for a) WT cells and b) HIF-1 deficient cells of both models. KEGG compound and reaction identifiers are indicated. Tyrosine and tyramine are contained in a box to denote that this metabolite was not definitively identified in the GC-MS analysis.