Figure 5.
Lentivirus-mediated overexpression of NDRG2 suppressed the in vivo growth of 22Rv1 xenografts following castration. Nude mice were injected subcutaneously with 22Rv1 cells stably expressing LacZ or NDRG2 and underwent castration therapy by orchectomy. (A) Tumor growth was monitored by assessing tumor volume (mm3) every week. (B) The tumor nodules were collected at the end of the experiment. (C) The tumor weight (g) was recorded. (D) Ratios of tumor weight/mouse weight were recorded. The curves and histograms were drawn based on the average values (n = 6). Data indicate the mean ± SD *: P < 0.05; **: P < 0.01.