Table 1.
Effect of aripiprazole pretreatment on METH-induced stereotypy in mice.
| HEAD-BOBBING | CIRCLING | SNIFFING | BITING | TOTAL STEREOTYPY | |
|---|---|---|---|---|---|
| Challenge: saline | |||||
| Vehicle pretreatment (n = 8) | N.D. | N.D. | 0.5 ± 0.3 | 0.5 ± 0.3 | 1.0 ± 0.5 |
| 1 mg/kg aripiprazole (n = 7) | N.D. | 0.1 ± 0.1 | N.D. | N.D. | 0.1 ± 0.1 |
| 10 mg/kg aripiprazole (n = 7) | N.D. | N.D. | N.D. | N.D. | N.D. |
| Challenge: 10 mg/kg METH | |||||
| Vehicle pretreatment (n = 8) | 1.1 ± 0.6 | N.D. | 10.6 ± 9.2* | 80.0 ± 10.0* | 91.8 ± 2.6* |
| 1 mg/kg aripiprazole (n = 7) | N.D. | N.D. | 30.9 ± 8.2*,† | N.D.† | 30.9 ± 8.2*,† |
| 10 mg/kg aripiprazole (n = 7) | N.D. | N.D. | 5.6 ± 4.3*,‡ | 0.3 ± 0.2† | 5.9 ± 4.3†,‡ |
Notes: Expression pattern of stereotypical behavior after METH injection (frequency of observation for 30-second bins over 60 minutes). Mice were injected with 10 mg/kg of METH or saline 30 minutes after pretreatment with aripiprazole (1 or 10 mg/kg) or vehicle. Values are expressed as number of 30-second bins in which each behavior was the predominant behavior for 60 minutes after METH injection (mean ± SEM). N.D., not detected (ie, 0.0 ± 0.0).
P < 0.05, compared with corresponding group challenged with saline (one-way ANOVA followed by a post hoc Fisher’s PLSD test).
P < 0.05, compared with corresponding group pretreated with vehicle (one-way ANOVA followed by a post hoc Fisher’s PLSD test).
P < 0.05, compared with corresponding group pretreated with 1 mg/kg aripiprazole (one-way ANOVA followed by a post hoc Fisher’s PLSD test).