Table 2.

Effect of aripiprazole posttreatment on METH-induced stereotypy in mice.

	HEAD-BOBBING	CIRCLING	SNIFFING	BITING	TOTAL STEREOTYPY
0–25 minutes after METH
10 mg/kg METH (n = 32)	0.9 ± 0.2	0.9 ± 0.2	6.3 ± 0.5	16.4 ± 0.8	24.5 ± 0.6
45–85 minutes after METH
Vehicle (n = 8)	N.D.	N.D.	4.8 ± 1.4	75.1 ± 1.4	79.9 ± 0.1
0.1 mg/kg aripiprazole (n = 8)	N.D.	N.D.	15.5 ± 5.6*	57.0 ± 6.6	72.6 ± 0.2
1 mg/kg aripiprazole (n = 8)	N.D.	N.D.	21.5 ± 1.9*	5.3 ± 2.1*,†	26.8 ± 2.9*,†
10 mg/kg aripiprazole (n = 8)	N.D.	N.D.	2.9 ± 1.1†,‡	0.5 ± 0.3*,†	3.4 ± 1.4*,†,‡

Notes: Expression pattern of stereotypical behavior after METH injection (frequency of observation for 30-second bins over 60 minutes). Mice were injected with 10 mg/kg of METH for 25 minutes of behavioral measures followed by treatment of aripiprazole (0.1, 1, or 10 mg/kg) or vehicle. Twenty minutes after aripiprazole (or vehicle) treatment, behavioral measures were assessed again. Values are expressed as number of 30-second bins in which each behavior was the predominant behavior for 0–25 and 45–85 minutes after METH injection (mean ± SEM). N.D., not detected (ie, 0.0 ± 0.0).

^*P < 0.05, compared with group treated with vehicle (one-way ANOVA followed by a post hoc Fisher’s PLSD test).

^†P < 0.05, compared with group treated with 0.1 mg/kg aripiprazole (one-way ANOVA followed by a post hoc Fisher’s PLSD test).

^‡P < 0.05, compared with group treated with 1 mg/kg aripiprazole (one-way ANOVA followed by a post hoc Fisher’s PLSD test).