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. Author manuscript; available in PMC: 2015 Oct 28.

Published in final edited form as: Eur J Immunol. 2000 Jul;30(7):2015–2026. doi: 10.1002/1521-4141(200007)30:7<2015::AID-IMMU2015>3.0.CO;2-5

Table 1.

Nature and distribution of the somatic mutations in the mAb 412.67 V(D)J genes

Mutations	V_HDJ_H				V_κJ_κ

	CDR		FR		CDR		FR

	R	S	R	S	R	S	R	S
Observed	6	1	2	2	3	0	1	1
Expected^a)	2.53		5.73		0.96		2.78
Probability^b)	p = 0.02		p = 0.02		p = 0.05		p = 0.11

^a)

Theoretically expected R mutations on the basis of chance alone.

^b)

Probability of R mutations arising by chance alone.