Figure 2. HTR Connectivity Map of 50 pathogens.
(a) Heat map representation of association scores for HTR connectivities among 50 pathogens (a heat map of association scores calculated based on individual pathogen strain is in Supplementary Figure S1). The association scores among these 50 mPRLs are reported with corresponding P values and FDR values in Supplementary Data S5. The color of each cell represents the HTR connectivity association score computed for the mPRLs of each pathogen pair, with red representing positive connectivity and blue representing negative connectivity. Distributions of association scores for 1,225 pairs of HTRs among (b) all 50 mapped pathogens, (c) the 27 mapped non-viral pathogens (21 bacterial species, 5 protozoans, and 1 fungus), and (d) the 23 mapped viral pathogens, as approximated to normal distributions. All distribution patterns were in accordance with Gaussian distribution, and presented as means with standard deviations, i.e., 0.0447 ± 0.0987 (50 pathogens), 0.0711 ± 0.1153 (non-viral pathogens), and 0.0278 ± 0.0931 (viral pathogens). All distributions deviated from their expected zero centers (P = 7.67 × 10−52, 1.07 × 10−26, and 1.70 × 10−6 for all 50, non-viral subset, and viral subset, respectively, two-sample t-tests).