Table 1.
24-Hour and 8-Hourly Hormonal Exposure in patients with Classic CAH on treatment
| Geometric mean (10th to 90th percentiles) | AUC (24 hours) [23:00 – 23:00] | AUC (23:00 – 07:00) | AUC (07:00 – 15:00) | AUC (15:00 – 23:00) |
|---|---|---|---|---|
| ACTH (pmol/L.hr) | 257 (38 – 1227) | 45 (8 – 383) | 106 (11 – 631) | 82 (15 – 417) |
| 17OHP (nmol/L.hr) | 633 (19 – 7113) | 122 (5 – 2066) | 265 (8 – 3784) | 199 (5 – 1700) |
| Androstenedione (nmol/L.hr) | 179 (30 – 1081) | 51 (11 – 325) | 65 (10 – 453) | 59 (9 – 303) |
| Androsterone (nmol/L.hr) | 121 (44 – 478) | 33 (11 – 130) | 43 (13 – 192) | 42 (14 – 157) |
| DHEA (nmol/L.hr) | 42 (10 – 730) | 13 (3 – 115) | 16 (3 – 344) | 12 (3 – 301) |
| Testosterone (males) (nmol/L.hr) | 321 (127 – 2037) | 109 (23 – 1536) | 105 (52 – 248) | 90 (36 – 252) |
| Testosterone (females) (nmol/L.hr) | 40 (22 – 131) | 12 (6 – 41) | 14 (7 – 42) | 14 (8 – 47) |
| Progesterone (males) (nmol/L.hr) | 17.0 (1.2 – 543.8) | 4.4 (0.3 – 197.2) | 6.5 (0.2 – 286.2) | 4.3 (0.2 – 184.1) |
| Progesterone (females) (nmol/L.hr) | 58.8 (13.4 – 1329.2) | 6.6 (0.2 – 321.2) | 23.2 (2.3 – 537.4) | 22.2 (6.4 – 470.6) |
AUC, area under the curve