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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Ann Neurol. 2015 Sep 16;78(5):697–709. doi: 10.1002/ana.24493

Figure 2.

Figure 2

Thioflavin-S fluorescence photomicrograph of neurofibrillary tangles in all three AD pathologic variants. For each variant, compare the burden of neurofibrillary tangles in the hippocampus CA1 region versus the burden of neurofibrillary tangles in the frontal cortex (BA9/46). With Limbic AD pathology, greater burden of neurofibrillary tangles is observed in the hippocampus, while in Hippocampal Sparing AD pathology greater burden is observed in the frontal cortex. In Typical AD the burden of neurofibrillarly tangles in the hippocampus and frontal cortex are similar. Images are all X200 (Insets are X400). Scale bar in panel b represents 50 microns; scale bar in inset of panel b is 25 microns.