Table 2.
Subject characteristics by pathological subtype of AD and TDP-43 status (unless otherwise indicated values shown are median (range)).
| Total N = 188 |
HpSp AD N = 19 |
Typical AD N = 136 |
Limbic AD N = 33 |
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|---|---|---|---|---|---|---|---|
|
| |||||||
| TDP+ N = 4 |
TDP− N = 15 |
TDP+ N = 80 |
TDP− N = 56 |
TDP+ N = 22 |
TDP− N = 11 |
||
| No. Female, n (%) | 107 (57%) | 1 (25%) | 6 (40%) | 49 (61%) | 29 (52%) | 14 (64%) | 8 (73%) |
| Education, yrs. | 14 (8, 20) | 16 (12, 18) | 16 (8, 20) | 12 (8, 20) | 15 (8, 20)* | 14 (8, 18) | 12 (8, 20) |
| APOE ε 4 carrier, n (%) | 110 (59%) | 1 (25%) | 11 (73%) | 50 (62%) | 24 (43%)* | 17 (77%) | 7 (64%) |
| Age at onset, yrs. | 74 (42, 96) | 69 (62, 76) | 59 (48, 79) | 76 (50, 96) | 68 (42, 87)*** | 78 (67, 88) | 79 (75, 93) |
| Age at death, yrs. | 85 (51, 104) | 79 (70, 88) | 68 (55, 86) | 86 (56, 104) | 81 (51, 100)** | 87 (76, 100) | 92 (84, 96) |
| Time from onset to death, yrs. | 9 (2, 27) | 10 (7, 12) | 8 (5, 13) | 9 (2, 27) | 10 (4, 20) | 11 (4, 19) | 8 (3, 16) |
| Cognitively normal at death, n (%) | 13 (7%) | 0 (0%) | 0 (0%) | 2 (2%) | 10 (18%)*** | 0 (0%) | 1 (9%) |
| Presentation, n (%) | |||||||
| Amnestic AD Dementia | 136 (74%) | 0 (0%) | 8 (53%) | 67 (84%) | 30 (56%) | 21 (100%) | 10 (91%) |
| Atypical AD Dementia | 36 (19%) | 4 (100%) | 7 (47%) | 11 (14%) | 14 (26%) | 0 (0%) | 0 (0%) |
| Braak stage, n (%) | |||||||
| 4 | 18 (10%) | 0 (0%) | 0 (0%) | 8 (10%) | 9 (16%) | 0 (0%) | 1 (9%) |
| 5 | 52 (28%) | 0 (0%) | 2 (13%) | 21 (26%) | 16 (29%) | 8 (36%) | 5 (45%) |
| 6 | 118 (63%) | 4 (100%) | 13 (87%) | 51 (64%) | 31 (55%) | 14 (64%) | 5 (45%) |
| CERAD Frequent, n (%) | 132 (70%) | 2 (50%) | 13 (87%) | 56 (70%) | 40 (71%) | 12 (55%) | 9 (82%) |
| Infarction, n (%) | 41 (22%) | 0 (0%) | 1 (7%) | 20 (25%) | 11 (20%) | 6 (27%) | 3 (27%) |
| Hippocampal sclerosis positive, n (%) | 33 (18%) | 2 (50%) | 1 (7%) | 15 (19%) | 5 (9%) | 10 (45%) | 0 (0%)* |
| Lewy bodies Positive, n (%) | 62 (33%) | 2 (50%) | 6 (40%) | 30 (38%) | 14 (25%) | 8 (36%) | 2 (18%) |
| TDP stage, n (%) | |||||||
| Stage I | 21 (20%) | 0 (0%) | - | 16 (20%) | - | 5 (24%) | - |
| Stage II | 30 (29%) | 1 (25%) | - | 27 (34%) | - | 2 (10%) | - |
| Stage III | 33 (31%) | 1 (25%) | - | 22 (28%) | - | 10 (48%) | - |
| Stage IV | 19 (18%) | 1 (25%) | - | 14 (18%) | - | 4 (19%) | - |
| Stage V | 2 (2%) | 1 (25%) | - | 1 (1%) | - | 0 (0%) | - |
Pairwise comparison within AD subtype;
*
p < 0.05,
**
p < 0.01.
***
p < 0.001. P-values were from Fishers Exact and Wilcoxon rank sum tests.