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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Immunol. 2015 Jun 4;68(2 0 0):116–119. doi: 10.1016/j.molimm.2015.05.016

Figure 1. Functions of IgE and its high affinity receptor FcεRI on DCs.

Figure 1

So far DCs have been demonstrated to use IgE/FcεRI for antigen uptake via receptor crosslinking. Antigens taken up by this mechanism are shuttled efficiently into endo/lysosomal compartments for loading and presentation on MHC class II molecules. Notably, the induced proliferation and differentiation of naïve T cells is not skewed towards a specific T helper cell type. Furthermore, internalization of FcεRI after monovalent ligation of FcεRI with IgE or with an antigen-conjugated IgE fusion protein was reported. Interestingly, antigen uptake via monovalently ligated FcεRI leads to antigen-specific T cell tolerance. Whether antigen is shuttled and processed differently after mono- or multivalent FcεRI crosslinking for antigen presentation on MHC class-II molecules is not yet known.