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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Lancet Diabetes Endocrinol. 2015 Sep 13;3(11):866–875. doi: 10.1016/S2213-8587(15)00291-0

Figure 3.

Figure 3

Prevalence of aggregate microvascular complication and individual microvascular components by DPPOS end (2012–2013). Placebo (red solid), metformin (blue dotted pattern), lifestyle (green diagonal stripes). 3A. By treatment group. None of the treatment group differences achieved statistical significance for the aggregate or the microvascular components. The aggregate microvascular is expressed as the average prevalence among the 3 components of nephropathy, retinopathy and neuropathy. 3B. By pre-specified subgroups according to sex and diabetes status. Prevalence was greater in men than in women in each of the three treatment groups. In women, the prevalence of the aggregate microvascular outcome was 22% (relative risk 0.78, p=0.02) lower in the lifestyle intervention group compared with the metformin group and 21% (relative risk 0.79, p=0.03) lower than in the placebo group. There were no significant differences among the treatment groups in men. The prevalence of microvascular disease in participants who did not develop diabetes was 28% lower than that in those who developed diabetes in a treatment group adjusted model (p<0.0001).