Table 1. Overview of the biophysical properties for Kv2.1, Kv2.1/Kv6.4, Kv2.1/Kv6.4_S6c_Kv9.3 and Kv2.1/Kv9.3_S6c_Kv6.4 channels.
| Control | 18mM 4-AP | ||||||
|---|---|---|---|---|---|---|---|
| V 1/2 (mV) | k | n | V 1/2 (mV) | k | n | ||
| Activation | Kv2.1 | −2.0 ± 0.9 | 9.7 ± 0.5 | 6 | 15.4 ± 1.3 | 12.8 ± 0.8 | 6 |
| Kv6.3 | 5.6 ± 2.3 | 10.1 ± 0.6 | 7 | 13.8 ± 2.0 | 10.9 ± 1.4 | 5 | |
| Kv6.4 | 1.5 ± 1.4 | 20.0 ± 1.0 | 9 | −0.3 ± 1.9 | 21.3 ± 2.1 | 9 | |
| Kv6.4_S6c_Kv9.3 | −2.6 ± 1.0 | 13.2 ± 0.3 | 8 | −0.5 ± 1.2 | 15.5 ± 0.7 | 8 | |
| Kv9.3 | −5.7 ± 1.7 | 10.3 ± 0.2 | 5 | −7.0 ± 0.5 | 8.9 ± 0.6 | 5 | |
| Kv9.3_S6c_Kv6.4 | 6.7 ± 1.2 | 11.0 ± 0.9 | 6 | 4.8 ± 1.3 | 10.2 ± 0.3 | 6 | |
| Inactivation | Kv2.1 | −19.4 ± 2.3 | 6.3 ± 0.5 | 6 | −11.4 ± 1.0 | 5.6 ± 0.6 | 6 |
| Kv6.3 | -20.0 ± 3.8 | 6.9 ± 0.4 | 5 | -4.8 ± 1.5 | 8.0 ± 0.6 | 5 | |
| Kv6.4 | −59.0 ± 1.2 | 8.4 ± 0.4 | 7 | −52.0 ± 2.6 | 7.7 ± 0.1 | 7 | |
| Kv6.4_S6c_Kv9.3 | −58.5 ± 1.4 | 7.7 ± 0.2 | 5 | −56.8 ± 1.2 | 7.9 ± 0.8 | 5 | |
| Kv9.3 | −48.7 ± 1.4 | 7.0 ± 0.5 | 5 | −45.4 ± 1.2 | 7.8 ± 0.7 | 5 | |
| Kv9.3_S6c_Kv6.4 | −31.3 ± 0.7 | 7.3 ± 0.3 | 5 | −28.7 ± 2.0 | 8.4 ± 0.8 | 5 | |
V1/2, midpoint of activation and inactivation; k, slope factor; n, number of cells. Values in bold are significantly different (p < 0.05) compared to control values