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. Author manuscript; available in PMC: 2016 Oct 22.
Published in final edited form as: Cell. 2015 Oct 17;163(3):594–606. doi: 10.1016/j.cell.2015.09.055

Figure 6. Mutational order dictates specificity class of intermediate variants.

Figure 6

(A) Mutational paths from LWDK to LWKL for ParD3 with fitness of each variant against ParE2 and ParE3 shown as a heatmap: yellow, high fitness; black low fitness.

(B) The six path types that reprogram ParD3 specificity in two mutational steps. Percentage of mutational paths in each category is indicated for a threshold of 0.5 used to define a positive interaction.

Also see Fig. S6.