Table 1.
Pathologic evaluation of brain sections suggests differences in tumor density for GBM8‐shYes and –shLyn vs. –NT tumors, as well as differences in invasiveness for GBM8‐shLyn vs. –NT tumors. Numbers are the number of brains with each classification; N = 12 NT, 7 shSrc, 7 shFyn, 6 shYes, 6 shLyn.
| GBM8‐NT | GBM8‐shSrc | GBM8‐shFyn | GBM8‐shYes | GBM8‐shLyn | |
|---|---|---|---|---|---|
| Microvasculature rating: | |||||
| Little | 5 (42%) | 4 (57%) | 3 (43%) | 4 (67%) | 3 (50%) |
| Increased | 7 (58%) | 3 (43%) | 4 (57%) | 2 (33%) | 3 (50%) |
| Tumor density: | |||||
| Moderate | 6 (50%) | 5 (71%) | 4 (57%) | 0 (0%) | 0 (0%) |
| High | 6 (50%) | 2 (29%) | 3 (43%) | 6 (100%) | 6 (100%) |
| Invasiveness: | |||||
| Moderate | 1 (8%) | 2 (29%) | 1 (14%) | 1 (17%) | 5 (83%) |
| High | 11 (92%) | 5 (71%) | 6 (86%) | 5 (83%) | 1 (17%) |