Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Pharmacol Ther. 2015 Aug 20;155:105–116. doi: 10.1016/j.pharmthera.2015.08.007

Figure 1. Distinct roles of secreted and nuclear CTSL.

Figure 1

Secreted CTSL aids metastatic dissemination of tumor cells by degrading cell adhesion molecules and extracellular matrix proteins as well as activating other latent proteases. Nuclear CTSL activates the transcription of epithelial to mesenchymal transition genes and also confers therapeutic resistance.