Table 1.
Baseline characteristics.
| CHARACTERISTIC | ALL HPV+ PATIENTS (N=178) | NO MATTED NODES (N=148) | MATTED NODES (N=30) | ||||
|---|---|---|---|---|---|---|---|
| Median | Range | Median | Range | Median | Range | p-value* | |
| Age (years) | 55.2 | 34.1–78.1 | 56.3 | 34.1 – 78.1 | 53.9 | 42.0 – 75.1 | 0.24 |
| Smoking Pack-years | 6 | 0–140 | 10 | 0 – 140 | 1.5 | 0 – 100 | 0.20 |
| No. of pts | % | No. of pts | % | No. of pts | % | ||
| Male | 160 | 89.9% | 131 | 88.5% | 29 | 96.7% | 0.26 |
| Smoking History | |||||||
| <10 pk yrs | 92 | 51.7% | 75 | 50.7% | 19 | 63.3% | 0.31 |
| ≥ 10 pk yrs | 86 | 48.3% | 73 | 49.3% | 11 | 36.7% | |
| Never | 66 | 37.1% | 52 | 35.1% | 14 | 46.7% | 0.27# |
| Former | 61 | 34.3% | 52 | 35.1% | 9 | 30.0% | |
| Current | 51 | 28.7% | 44 | 29.7% | 7 | 23.3% | |
| T-classification | |||||||
| T1 | 27 | 15.2% | 21 | 14.2% | 6 | 20.0% | 0.37# 0.047** |
| T2 | 69 | 38.8% | 60 | 40.5% | 9 | 30.0% | |
| T3 | 34 | 19.1% | 32 | 21.6% | 2 | 6.7% | |
| T4 | 48 | 27.0% | 35 | 23.6% | 13 | 43.3% | |
| N-classification | |||||||
| N0 | 10 | 5.6% | 10 | 6.8% | 0 | 0.0% | <0.001# |
| N1 | 13 | 7.3% | 13 | 8.8% | 0 | 0.0% | |
| N2a | 14 | 7.9% | 14 | 9.5% | 0 | 0.0% | |
| N2b | 74 | 41.6% | 67 | 45.3% | 7 | 23.3% | |
| N2c | 42 | 23.6% | 30 | 20.3% | 12 | 40.0% | |
| N3 | 25 | 14.0% | 14 | 9.5% | 11 | 36.7% | |
| Radiographic Extracapsular Spread | 115 | 64.6% | 85 | 57.4% | 30 | 100.0% | <0.001 |
| Consolidative Neck Dissection | 40 | 22.5% | 30 | 20.3% | 10 | 33.3% | 0.19 |
| HPV+ Risk-Group | |||||||
| Low Risk (T1-3, N0-2c, <10 pk-yrs) | 57 | 32.0% | 52 | 35.1% | 5 | 16.7% | <0.001# |
| Intermediate Risk (T1-3, N0-2c, ≥10 pk-yrs) | 54 | 30.3% | 50 | 33.8% | 4 | 13.3% | |
| High Risk (T4 or N3) | 67 | 37.6% | 46 | 31.1% | 21 | 70.0% | |
*
Independent samples T-test or Chi-square test for comparison between patients with and without matted lymph nodes
#
Chi-square for trend
**
Comparison of T4 vs. T1-3 classifications