Table 4.
Cox Regression Model for Recurrence and Survival Endpoints with Adjustment for Matted Nodes and Risk Group in HPV-Related Oropharyngeal Cancer
| Locoregional Failure | Distant Failure | Any Failure | Cause-Specific Mortality | All-Cause Mortality | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COVARIATE | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P |
| Low-Risk Group (T1-3, N0-2c, <10 pk-yrs) | Ref | – | – | Ref | – | – | Ref | – | – | Ref | – | – | Ref | – | – |
| Intermediate Risk Group (T1-3, N0-2c, ≥10 pk-yrs) | 5.0 | 0.8–18.9 | 0.087 | 3.7 | 0.4–35.5 | 0.25 | 3.9 | 1.1–14.1 | 0.039 | 7.5 | 0.9–60.6 | 0.059 | 5.5 | 1.2–24.8 | 0.028 |
| High Risk Group (T4 or N3) | 8.2 | 1.9–35.6 | 0.005 | 7.5 | 1.0 –57.9 | 0.054 | 7.70 | 2.3–25.4 | <0.001 | 7.1 | 0.9–53.9 | 0.060 | 7.1 | 1.7–30.4 | 0.009 |
| Matted Nodes (yes vs. no) | 2.0 | 0.8–4.8 | 0.15 | 52.2 | 11.6–234.8 | <0.001 | 6.15 | 3.3–11.6 | <0.001 | 12.5 | 5.1–30.4 | <0.001 | 5.1 | 2.5–10.2 | <0.001 |
CI = confidence interval; HR = Hazard Ratio; Ref = Reference