Table 5.
Cox Regression Model for Recurrence and Survival Endpoints with Adjustment for Matted Nodes and Individual Risk Factors in HPV-Related Oropharyngeal Cancer
| Locoregional Failure | Distant Failure | Any Failure | Cause-Specific Mortality | All-Cause Mortality | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COVARIATE | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P |
| T-classification (T4 vs. T1-3) | 2.0 | 0.9–4.4 | 0.091 | 14.3 | 3.6–56.5 | <0.001 | 3.0 | 1.6–5.7 | <0.001 | 2.6 | 1.1–6.1 | 0.025 | 2.9 | 1.5–5.6 | 0.002 |
| N-classification (N3 vs. N0-2c) | 3.2 | 1.3–7.8 | 0.013 | 1.5 | 0.5–4.2 | 0.49 | 2.2 | 1.1–4.3 | 0.033 | 1.3 | 0.4–3.3 | 0.65 | 1.4 | 0.6–3.1 | 0.44 |
| Smoking Pack-years (≥10 vs. <10) | 1.2 | 0.6–2.6 | 0.66 | 5.6 | 1.7–18.8 | 0.006 | 1.7 | 0.9–3.2 | 0.090 | 1.5 | 0.7–3.4 | 0.32 | 1.6 | 0.8–3.2 | 0.15 |
| Matted Nodes (yes vs. no) | 1.9 | 0.7– 4.8 | 0.20 | 152.4 | 26.9–864.3 | <0.001 | 7.2 | 3.7 –14.3 | <0.001 | 14.1 | 5.8–34.2 | <0.001 | 6.4 | 3.1 – 13.0 | <0.001 |
CI = confidence interval; HR = Hazard Ratio