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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Addict Biol. 2015 Apr 27;21(3):613–633. doi: 10.1111/adb.12252

Figure 1.

Figure 1

Summary of the effects of our unpredictable chronic mild stress (UCMS) procedures upon alcohol-induced locomotion in 3 different cohorts of Swiss-Webster mice. (A) In the cross-sensitization study (n=12/group), an acute injection with 2 g/kg alcohol (EtOH; solid bars) elevated locomotor activity during a 15-min test, relative to an equivalent volume injection of saline (SAL; open bars). Mice subjected to our UCMS procedures (UCMS) exhibited higher locomotor activity versus controls, regardless of alcohol administration. However, the greatest locomotor activity was observed in UCMS-EtOH mice. In both the studies of stress interactions with alcohol drinking (n=12/group) (B) and alcohol intoxication (n=9 for Control; n=10 for UCMS) (C), mice subjected to our UCMS procedures also exhibited a greater locomotor response to 2 g/kg alcohol during a 15-min test than did animals subjected to our control procedures. *p<0.05 vs. SAL; +p<0.05 vs. Control (t-tests).