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. Author manuscript; available in PMC: 2015 Oct 28.
Published in final edited form as: Arthritis Rheumatol. 2015 Jan;67(1):28–38. doi: 10.1002/art.38904

Table 3.

Levels of MMP-7 and IP-10 among patients in the RA cohorts, by degree of ILD*

MMP-7 IP-10
Mean ± SD
ng/ml		 P vs.
RA–no ILD		 Mean ± SD
ng/ml		 P vs.
RA–no ILD
Chinese identification cohort†
  RA–no ILD (ILA score 0) (n = 49) 3.06 ± 1.73 – 173.8 ± 96.1 0.01
  RA–indeterminate ILD (ILA score 1) (n = 42) 4.00 ± 1.88 0.02 322.5 ± 388.7 0.002
  RA–mild ILD (ILA score 2) (n = 38) 4.77 ± 3.70 0.02 292.7 ± 232.7 NA
  RA–advanced ILD (ILA score 3) (n = 3) 12.73 ± 8.52 NA 510.4 ± 211.5 0.0004
  RA-ILD (ILA score 2 or 3) (n = 41) 5.35 ± 4.55 0.005 308.6 ± 235.8 0.01
US replication cohort‡
  RA–no ILD (ILA score 0) (n = 22) 2.98 ± 1.32 – 83.3 ± 79.3 0.05
  RA–indeterminate ILD (ILA score 1) (n = 15) 4.13 ± 2.13 0.09 233.3 ± 372.1 0.009
  RA–mild ILD (ILA score 2) (n = 34) 5.82 ± 3.37 ±0.0001 220.0 ± 337.5 0.05
  RA–advanced ILD (ILA score 3) (n = 7) 8.01 ± 3.24 0.0003 177.6 ± 144.4 0.001
  RA-ILD (ILA score 2 or 3) (n = 49)§ 6.16 ± 3.37 ±0.0001 209.7 ± 288.2 0.05
*

NA = not available (see Table 1 for other definitions).

†

Results of logistic regression analysis for matrix metalloproteinase 7 (MMP-7) were as follows: unadjusted odds ratio (OR) 1.0003 (95% confidence interval [95% CI] 1.000–1.001), P = 0.003; age-adjusted OR 1.0002 (95% CI 1.000–1.000), P = 0.03; 28-joint DAS (3-variable)–adjusted OR 1.0003 (95% CI 1.000–1.001), P = 0.005. Results of logistic regression analysis for interferon-γ–inducible protein 10 (IP-10) were as follows: unadjusted OR 1.006 (95% CI 1.002–1.010), P = 0.003; age-adjusted OR 1.006 (95% CI 1.002–1.010), P = 0.006; 28-joint DAS–adjusted OR 1.005 (95% CI 1.001–1.009), P = 0.02.

‡

Results of logistic regression analysis for MMP-7 were as follows: unadjusted OR 1.0007 (95% CI 1.000–1.001), P = 0.001; age-adjusted OR 1.0006 (95% CI 1.000–1.001), P = 0.04; 28-joint DAS–adjusted OR 1.0009 (95% CI 1.000–1.002), P = 0.02. Results of logistic regression analysis for IP-10 were as follows: unadjusted OR 1.009 (95% CI 1.002–1.016), P = 0.01; age-adjusted OR 1.006 (95% CI 0.998–1.014), P = 0.15; 28-joint DAS–adjusted OR 1.014 (95% CI 1.002–1.026), P = 0.02.

§

Includes 8 individuals with definite RA-ILD in whom a score of 2 versus 3 could not be distinguished.