Table 3.
MMP-7 | IP-10 | |||
---|---|---|---|---|
Mean ± SD ng/ml |
P vs. RA–no ILD |
Mean ± SD ng/ml |
P vs. RA–no ILD |
|
Chinese identification cohort† | ||||
RA–no ILD (ILA score 0) (n = 49) | 3.06 ± 1.73 | – | 173.8 ± 96.1 | 0.01 |
RA–indeterminate ILD (ILA score 1) (n = 42) | 4.00 ± 1.88 | 0.02 | 322.5 ± 388.7 | 0.002 |
RA–mild ILD (ILA score 2) (n = 38) | 4.77 ± 3.70 | 0.02 | 292.7 ± 232.7 | NA |
RA–advanced ILD (ILA score 3) (n = 3) | 12.73 ± 8.52 | NA | 510.4 ± 211.5 | 0.0004 |
RA-ILD (ILA score 2 or 3) (n = 41) | 5.35 ± 4.55 | 0.005 | 308.6 ± 235.8 | 0.01 |
US replication cohort‡ | ||||
RA–no ILD (ILA score 0) (n = 22) | 2.98 ± 1.32 | – | 83.3 ± 79.3 | 0.05 |
RA–indeterminate ILD (ILA score 1) (n = 15) | 4.13 ± 2.13 | 0.09 | 233.3 ± 372.1 | 0.009 |
RA–mild ILD (ILA score 2) (n = 34) | 5.82 ± 3.37 | ±0.0001 | 220.0 ± 337.5 | 0.05 |
RA–advanced ILD (ILA score 3) (n = 7) | 8.01 ± 3.24 | 0.0003 | 177.6 ± 144.4 | 0.001 |
RA-ILD (ILA score 2 or 3) (n = 49)§ | 6.16 ± 3.37 | ±0.0001 | 209.7 ± 288.2 | 0.05 |
NA = not available (see Table 1 for other definitions).
Results of logistic regression analysis for matrix metalloproteinase 7 (MMP-7) were as follows: unadjusted odds ratio (OR) 1.0003 (95% confidence interval [95% CI] 1.000–1.001), P = 0.003; age-adjusted OR 1.0002 (95% CI 1.000–1.000), P = 0.03; 28-joint DAS (3-variable)–adjusted OR 1.0003 (95% CI 1.000–1.001), P = 0.005. Results of logistic regression analysis for interferon-γ–inducible protein 10 (IP-10) were as follows: unadjusted OR 1.006 (95% CI 1.002–1.010), P = 0.003; age-adjusted OR 1.006 (95% CI 1.002–1.010), P = 0.006; 28-joint DAS–adjusted OR 1.005 (95% CI 1.001–1.009), P = 0.02.
Results of logistic regression analysis for MMP-7 were as follows: unadjusted OR 1.0007 (95% CI 1.000–1.001), P = 0.001; age-adjusted OR 1.0006 (95% CI 1.000–1.001), P = 0.04; 28-joint DAS–adjusted OR 1.0009 (95% CI 1.000–1.002), P = 0.02. Results of logistic regression analysis for IP-10 were as follows: unadjusted OR 1.009 (95% CI 1.002–1.016), P = 0.01; age-adjusted OR 1.006 (95% CI 0.998–1.014), P = 0.15; 28-joint DAS–adjusted OR 1.014 (95% CI 1.002–1.026), P = 0.02.
Includes 8 individuals with definite RA-ILD in whom a score of 2 versus 3 could not be distinguished.