. 2015 Oct 20;109(8):1652–1662. doi: 10.1016/j.bpj.2015.08.028

Table 3.

Lipid binding and receptor deactivation in simulations with anionic lipids

No. of Distinct Lipid Binding Events^a^,^b	% of Lipid-Bound R3.50^b (%)	% of Simulations Exhibiting		% of Time		Active State Half-Life (μs)
H3–H6 Closure^c	Ionic Lock^d	Closed^c	Locked^d
83	14 ± 1	12 ± 0	21 ± 2	4 ± 2	2 ± 1	9.4 ± 1.6

Not counting rebinding of a previously bound lipid.

Minimum N_η-O distance between R3.50 and a lipid, d_R3.50-lipid < 0.35 nm.

C_α distance between R3.50 and L6.34, d_H3–H6 < 0.94 nm.

Minimum N_η-O_ε distance between R3.50 and E6.30, d_lock < 0.35 nm.