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. 2015 Oct 20;109(8):1698–1705. doi: 10.1016/j.bpj.2015.08.041

Figure 8.

Figure 8

Accommodation of the Leu 17 side chain in a groove when type I AFP mutant docks to the {100} hydrate planes. (A and B) The side chain of Leu 17 (purple stick representation) is shown, with waters that form one groove 2 on the {100} planes (red spheres) and their hydrogen bonds (black dashed lines) also indicated. (A) Top view. (B) Side view. (C and D) As a comparison, the docking of Ala 17 in the same groove where the wild-type binds is also shown. (C) Top view. (D) Side view. To see this figure in color, go online.