Table 2.

Drug-induced adverse events according to the common terminology criteria for adverse events version 3.0 or 4.0

	All grades	Grade 3 or 4
	No. (%)	No. (%)
Adverse events	181 (94.8)	103 (53.9)
Hand-foot skin reaction	120 (62.8)	38 (19.9)
Elevated AST	114 (59.7)	26 (13.6)
Elevated ALT	103 (53.9)	14 (7.3)
Fatigue	98 (51.3)	13 (6.8)
Appetite loss	84 (44.0)	20 (10.5)
Diarrhea	76 (39.8)	12 (6.3)
Hypertension	73 (38.2)	11 (5.8)
Skin rash	40 (20.9)	5 (2.6)
Voice changes	23 (12.0)	2 (1.0)
Alopecia	23 (12.0)	0 (0.0)
Gastrointestinal bleeding	4 (2.1)	1 (0.5)
Variceal bleeding	3 (1.6)	2 (1.0)

ALT alanine aminotransferase, AST aspartate aminotransferase