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. Author manuscript; available in PMC: 2015 Oct 28.
Published in final edited form as: J Med Chem. 2015 Jul 31;58(15):6002–6017. doi: 10.1021/acs.jmedchem.5b00571

Scheme 2.

Scheme 2

Synthesis of 3-(Benzylidene)indolin-2-one Derivativesa

aReagents: (a) CH3COOH, reflux 3 h; (b) 1) NaH, DMF, 2) CH3I, or R-C6H4CH2X (X = Cl, Br); (c) Fe, CH3OH, HCl, reflux 3 h.