Scheme 3.
Synthesis of Labeling Precursor 48 and Radiosynthesis of [18F]46a
Reagents: (a) 1) NaH, DMF, 2) BrCH2C6H4OCH2CH2Br; (b) AgOMs, CH3CN; (c) [18F]KF, K2CO3, K222, tert-amyl alcohol.
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