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. 2015 Oct 27;10(10):e0141610. doi: 10.1371/journal.pone.0141610

Fig 3. Minor effects in neurological deficits and body weight gain presented by CMVMJD135 mice upon VPA treatment.

Fig 3

(A) Decreased body weight gain in CMVMJD135 VPA-treated animals compared to CMVMJD135 vehicle-treated animals; (B) no improvement of VPA-treated animals in grip strength as assessed through the hanging wire test; (C) Improvement in spontaneous locomotor activity at 24 weeks of age; (D,E,F) No improvement in spontaneous activity (vertical movement), in tremors and limb clasping, respectively, (G) transient improvement in footdragging severity at 14 weeks, and (H) tendency toward an improvement in stride length at 22 and 24 weeks of age. Bars represent the mean ± SEM (WT veh, n = 10; WT VPA, n = 15; CMVMJD135 vehicle, n = 10; CMVMJD135 VPA, n = 13), * represent p<0.05, ** represent p<0.01 and *** represent p<0.001, black asterisks represents the difference between WT and CMVMJD135, blue asterisks represents the difference between non-treated and VPA-treated CMVMJD135 (Repeated-measures ANOVA, Tukey correction for continuous variables, One-Way ANOVA for differences between groups in specific ages of the continuous variables and Chi-square Fisher’s exact test for categorical non-continuous variables).