Fig 1. Plasma in HAT patients display different ¹H NMR metabolic profiles compared with controls.

PCA model (A) and O-PLS-DA model (B) score plots of plasma ¹H NMR spectra across HAT patients and controls. Each circle represents a spectra from one sample, whereby patients are presented in red (n = 45) and controls in dark grey (n = 21). Abbreviations: R²X, model fit parameter for variation in spectral data; R²Y, model fit parameter for variation in classifier data (for O-PLS-DA); Q², model predictive parameter for spectral data in PCA (Q²X) and for classifier data in O-PLS-DA (Q²Y). Individual component contribution of R²X are shown on the axes as percentage.