Table 1. Discriminatory lipid species observed in plasma via UPLC-MS.
| Lipid Species | ESI+ | ESI- | |||
|---|---|---|---|---|---|
| P-value | % Difference | P-value | % Difference | ||
| Increased in HAT | Cer (d42:2) | - | - | 2.51E-03 | 54.30% |
| PC (32:0) | 2.49E-05 | 104.20% | 2.58E-03 | 111.70% | |
| PC (32:1) | - | - | 1.29E-04 | 62.50% | |
| PC (34:1) | - | - | 8.21E-03 | 35.00% | |
| PC (34:2) | - | - | 1.29E-04 | 40.20% | |
| PC(O-34:1)/ PC(P-34:0) | 3.93E-04 | 86.20% | 2.00E-03 | 84.30% | |
| PE (36:2) | - | - | 2.51E-03 | 54.40% | |
| PS (39:3) | - | - | 4.42E-03 | 37.50% | |
| SM (d34:1) | 1.75E-02 | 96.10% | - | - | |
| TG (51:2) | 6.52E-05 | 98.00% | - | - | |
| TG (52:3) | 4.40E-03 | 45.40% | - | - | |
| TG (53:2) | 6.73E-04 | 86.10% | - | - | |
| TG (53:3) | 4.02E-04 | 77.50% | - | - | |
| TG (54:2) | 3.74E-04 | 70.30% | - | - | |
| TG (54:5) | 2.20E-03 | 68.20% | - | - | |
| Decreased in HAT | CE (18:2) | 1.12E-04 | -53.10% | - | - |
| LysoPC (16:0) | 1.93E-05 | -58.60% | 5.42E-04 | -60.10% | |
| LysoPC (18:0) | 1.11E-04 | -72.60% | 4.42E-03 | -69.50% | |
| LysoPC (18:1) | 1.98E-05 | -66.50% | 1.00E-04 | -62.50% | |
| LysoPC (18:2) | 3.28E-04 | -80.50% | 3.18E-04 | -78.20% | |
| LysoPC (20:3) | 5.97E-05 | -75.00% | 7.00E-04 | -77.90% | |
| LysoPC (20:4) | 4.36E-06 | -75.60% | 2.62E-04 | -73.10% | |
| PC (40:5) | 1.13E-02 | -39.20% | - | - | |
| PC (36:3) | 6.56E-03 | -33.90% | - | - | |
| PC (38:3) | 1.93E-03 | -43.00% | 2.51E-03 | -30.70% | |
| PC (38:5) | 1.71E-02 | -40.90% | 1.29E-04 | -28.80% | |
| PC (38:6) | 1.63E-02 | -33.30% | - | - | |
| PC (40:4) | 3.25E-03 | -47.90% | - | - | |
| PC (40:6) | 2.94E-02 | -32.70% | - | - | |
| PC(O-34:3)/PC(P-34:2) | 8.43E-04 | -52.80% | - | - | |
| SM (d38:1) | - | - | 3.46E-03 | -37.60% | |
| SM (d39:1) | - | - | 4.42E-03 | -52.10% | |
| SM (d40:1) | 1.01E-03 | -43.90% | 3.46E-03 | -48.60% | |
| SM (d40:2) | - | - | 2.58E-03 | -60.20% | |
| SM (d41:1) | 1.06E-03 | -58.60% | 2.00E-03 | -48.20% | |
| SM (d41:2) | - | - | 4.42E-03 | -55.30% | |
| SM (d42:1) | - | - | 3.92E-04 | -52.50% | |
Molecular species that not detected in a particular electro-spray ionisation (ESI) mode were omitted from the table. For more description of detected lipid species (including retention times and mass/charge ratios) see supplementary S2 Table.
Abbreviations: -, no discriminatory marker detected that ionisation mode; Cer, ceramide; CE, cholesterol ester; LysoPC, lysophosphatidylcholine; LysoPE, lysophosphatidylethanolamine; NS, not statistically significant; PC, phosphatidylcholine; PE, phosphatidylehtanolamine; PS, phosphatidylserine; RT, retention time; SM, sphingomyelin.