Table 1.
Association between Functional Response in each ROI with Age and Working Memory Performance
| 2back > 1back ROIs |
# Voxels | Center of mass (xyz) |
Mean fit coefficient (Beta) |
Association between Age and Function (Standardized Regression Coefficient) |
Association between 2back > 1back Function and Performance (Standardized Regression Coefficient) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 > 0 | 2 > 0 | 2 > 1 | 1 > 0 | 2 > 0 | 2 > 1 | 2-back d’ | 2-back RT | ||||||
| Task-activated ROIs | |||||||||||||
| L prefrontal (IFG, MFG, SFG) | 427 | 25.8 | −8.5 | 41.5 | .05 | .17 | .12 | −.01 | −.42** | −.39** | .28 | −.24 | |
| R parietal (IPL, SPL) | 399 | −31.4 | 54.2 | 41.5 | .04 | .18 | .14 | .12 | −.31* | −.42** | .34* | −.23 | |
| L parietal (IPL, SPL) | 284 | 31.5 | 53.7 | 40.7 | .02 | .15 | .14 | .06 | −.37** | −.41** | .31* | −.22 | |
| R prefrontal (IFG, MFG) | 205 | −34.1 | −5.7 | 43.8 | .05 | .16 | .11 | .10 | −.28* | −.33* | .35* | −.25 | |
| R prefrontal (MFG) | 42 | −39.5 | −28.0 | 28.4 | .08 | .20 | .12 | −.14 | −.49** | −.36* | .40** † | −.26 | |
| R cerebellum | 35 | −25.7 | 62.9 | −22.6 | −.01 | .16 | .17 | .03 | .11 | .09 | −.06 | −.10 | |
| R prefrontal (MFG) | 32 | −35.4 | −48.0 | 18.0 | .10 | .23 | .13 | .11 | −.24 | −.40** | .21 | −.11 | |
| L cerebellum | 29 | 26.7 | 64.2 | −24.6 | .03 | .13 | .11 | .08 | .02 | −.03 | .07 | −.15 | |
| R insula & IFG | 25 | −35.6 | −18.8 | 7.4 | .07 | .16 | .09 | .04 | −.28* | −.34* | .18 | −.10 | |
| L caudate | 24 | 15.2 | 1.8 | 19.0 | −.02 | .03 | .05 | .09 | −.28* | −.38** | .22 | −.17 | |
| Task-deactivated ROIs | |||||||||||||
| B cingulate, posterior cingulate gyrus, & cuneus | 423 | 1.3 | 48.1 | 31.2 | −.13 | −.22 | −.09 | .19 | .37* | .34* | −.23 | .04 | |
| R insula & precentral gyrus | 420 | −44.5 | 15.8 | 25.1 | −.04 | −.14 | −.10 | .31* | .39** | .28 | −.11 | .01 | |
| B medial frontal gyrus | 211 | 5.8 | −45.4 | 22.3 | −.16 | −.28 | −.12 | .23 | .45** | .44** | −.33* | .09 | |
| L insula | 149 | 39 | 18.6 | 11.8 | −.03 | −.12 | −.09 | .38** | .31* | .07 | −.16 | .02 | |
| L hippocampus & parahippocampal gyrus | 33 | 22.6 | 36.5 | −0.7 | −.07 | −.12 | −.05 | .12 | .33* | .32* | −.27 | .04 | |
Note: Standardized regression coefficients for age and performance associations are adjusted for study.
*
p <.05.
**
Significant after Bonferroni correction.
†
Scatterplot of association shown in Supplementary Figure 1.
R = right, L = left, B = bilateral, IPL = inferior parietal lobule, IFG = inferior frontal gyrus, MFG = middle frontal gyrus, SFG = superior frontal gyrus.