Table 2.
Oxaliplatin IC50 values of oxaliplatin, GMP, oxaliplatin/GMP, NCP-1, NCP-2, and NCP-3 against AsPc-1 and BxPc-3 cells (the numbers in parenthesis refer to GMP concentrations).
| Oxaliplatin | GMP | Oxaliplatin/GMP (μM) | Zn Control* (μM) | NCP-1 (μM) | NCP-2 (μM) | NCP-3 (μM) | |
|---|---|---|---|---|---|---|---|
| AsPc-1 | 18.1±2.1 | (2.6±0.4) | 3.6±0.6 (1.4±0.3) | >50 (>20) | 3.5±0.5 (1.4±0.1) | 22.4±1.4 | (6.1±4.1) |
| BxPc-3 | 29.0±7.1 | (2.7±2.1) | 3.0±0.2 (1.2±0.1) | >50 (>20) | 4.8±2.2 (1.9±0.9) | 7.8±2.5 | (25.8±6.3) |
*
Zn Control does not contain oxaliplatin or GMP as they are used to study the toxicity of NCP excipients. The amount of Zn Control particle was the same as NCP-1 under the studied concentrations. Data are expressed as means±SD.