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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: Mol Cell. 2015 Oct 1;60(2):328–337. doi: 10.1016/j.molcel.2015.09.001

Figure 4. YAP-Mediator regulates transcriptional elongation via CDK9 recruitment.

Figure 4

A) Normalized CDK9 coverage around the promoter of YAP negative- and YRE-associated genes. Error bars = 95% CI B) Fold change of CDK9 occupancy upon siYT treatment around the promoter of YAP negative- and YRE-associated genes. Error bars = 95% CI C) Log2 (FC) of expression of YAP− vs. YAP+ genes in HuCCT1 cells treated with CDK9 inhibitors Flavopiridol and NVP-2. Error bars = 95% CI. D) Liver/Body weight ratio of mice overexpressing YAP for 1 week treated with vehicle or Flavopiridol. E) Model for YAP/Mediator-driven transcriptional elongation in active Hippo signaling (left) or inactive Hippo signaling (right). See also Figure S4.