Table 14.
Pharmacokinetic parameters of the four saponins after oral administration of 2 g extraction/kg, each value represents the mean ± standard deviation (n = 5).
| Compound | Cmax−1 (μg/mL) | Cmax−2 (μg/mL) | T max−1 (h) | T max−2 (h) | AUC0−t (μg/h/mL) |
|---|---|---|---|---|---|
| Macranthoidin B | 1.39 | 1.30 | 5 | 18 | 22.79 |
| Macranthoidin A | 1.88 | 2.35 | 5 | 18 | 39.01 |
| Dipsacoside B | 1.73 | 2.20 | 5 | 18 | 39.62 |
| Macranthoside B | 0.10 | 0.64 | – | 18 | 19.52 |
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; Tmax = time of peak plasma concentration.