Table 16.
Pharmacokinetic parameters obtained by analyzing plasma samples after administration of 10 mg/kg Flos Lonicerae extract to rabbits (n = 4).
| Parameters | Values |
|---|---|
| AUC (μg min/mL) | 140 ± 65.9 |
| Area under first moment curve (AUMC) (μg min2/mL) | 2.80 × 104 ± 1.73 × 104 |
| MRT (min) | 190 ± 38.3 |
| Variance of the mean residence time (VRT) (min.min) | 1.28 × 104 ± 2.66 × 103 |
| Kel (L/min) | 0.0130 ± 0.0023 |
| Tmax(min) | 34.7 ± 1.09 |
| Cmax (μg/mL) | 0.839 ± 0.350 |
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; MRT = mean residence time; Tmax = time of peak plasma concentration; Kel = elimination rate constant.