Table 20.
Estimated pharmacokinetic data on geniposide in rat blood following geniposide administration (10, 30, and 100 mg kg−1, intravenously).
| Parameters | Geniposide 10 mg/kg−1 |
Geniposide 30 mg/kg−1 |
Geniposide 100 mg/kg−1 |
|||
|---|---|---|---|---|---|---|
| With out acupuncture | With acupuncture | Without acupuncture | With acupuncture | Without acupuncture | With acupuncture | |
| A. Blood | ||||||
| AUC (min μgml−1) | 417 ± 17 | 486 ± 59 | 1102 ± 32 | 1235 ± 128 | 4759 ± 601 | 4233 ± 411 |
| MRT (min) | 15 ± 1 | 15 ± 1 | 18 ± 1 | 17 ± 2 | 17 ± 2 | 17 ± 2 |
| Cl (ml min−1 kg−1) | 24 ± 1 | 22 ± 2 | 27 ± 1 | 26 ± 3 | 23 ± 3 | 25 ± 2 |
| B. Liver | ||||||
| AUC (min μgml−1) | 550 ± 107 | 637 ± 76 | – | – | – | – |
| MRT (min) | 16 ± 2 | 19 ± 3 | – | – | – | – |
| C. Bile | ||||||
| AUC (min μgml−1) | 1039 ± 136 | 1001 ± 90 | – | – | – | – |
| MRT (min) | 37 ± 2 | 39 ± 1 | – | – | – | – |
| AUC liver/AUC blood | 1.34 ± 0.27 | 1.41 ± 0.24 | – | – | – | – |
| AUC bile/AUC blood | 2.50 ± 0.33 | 2.10 ± 0.10 | – | – | – | – |
Data are expressed as mean ± standard error of the mean from six individual micro-dialysis experiments at each dose treatment.
AUC = area under the concentration-time curve; Cl = clearance; MRT = mean residence time.