Table 28.
Pharmacokinetic parameters of mangiferin after oral and intravenous administration to rats.
| Parameter | Oral administration (n = 6) | Intravenous administration (n = 6) |
|---|---|---|
| AUC(0–t) (μg/L h) | 1855.0 ± 887.7 | 61184.1 ± 22471.4 |
| AUC(0–∞) (μg/L h) | 2036.2 ± 942.2 | 62065.2 ± 23013.2 |
| T1/2 (h) | 3.2 ± 0.6 | 0.9 ± 0.4 |
| Tmax (h) | 2.5 ± 0.8 | 0.083 |
| MRT0–t (h) | 4.3 ± 0.5 | 1.3 ± 0.2 |
| Cmax (μg/L) | 301.3 ± 133.0 | 67798.3 ± 31235.9 |
| CLz (L/h kg) | (13.95 ± 4.64) × F | 0.15 ± 0.04 |
AUC = area under the concentration-time curve; Cmax – peak plasma concentration; MRT = mean residence time; Tmax = time of peak plasma concentration.