Table 30.
Pharmacokinetic parameters for metabolites in rat plasma after oral administration of 200 mg/kg tectoridin.
| Parameters | Te-7G-4′S | Te-7G | Te-7S | Tectorigenin |
|---|---|---|---|---|
| Tmax (h) | 3.50 ± 1.87 | 3.17 ± 1.81 | 5.58 ± 3.07 | 4.92 ± 2.87 |
| Cmax (μmol/L) | 21.4 ± 13.8 | 20.5 ± 9.70 | 14.3 ± 3.30 | 8.67 ± 3.07 |
| AUC(0–t) (μmol/L) | 164 ± 52 | 184 ± 73 | 123 ± 63 | 72.0 ± 22.0 |
| AUC(0–∞) (μmol/L) | 197 ± 79 | 198 ± 78 | 199 ± 91 | 98.0 ± 47.7 |
| MRT(0–t) (h) | 9.79 ± 4.47 | 10.7 ± 4.30 | 8.12 ± 3.37 | 8.54 ± 2.01 |
| MRT(0–∞) (h) | 20.4 ± 16.7 | 13.7 ± 6.00 | 15.9 ± 7.12 | 12.5 ± 3.90 |
| CL/F (L/h/kg) | 2.13 ± 0.96 | 2.35 ± 0.76 | 3.28 ± 1.85 | 8.13 ± 3.57 |
| V/F (L/kg) | 31.3 ± 13.8 | 31.0 ± 23.1 | 37.9 ± 20.9 | 80.7 ± 33.1 |
Data are mean ± standard deviation (n = 6).
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; MRT = mean residence time; Tmax = time of peak plasma concentration; CL/F = apparent plasma clearance.