Table 32.
Pharmacokinetic parameters of hederacolchiside E after oral administration of SKPC-B70M at a dose of 400 mg/kg in male Sprague Dawley rats.
| Parameter | SK-PC-B70M |
||
|---|---|---|---|
| 100 mg/kg | 200 mg/kg | 400 mg/kg | |
| AUC (μg h/mL) | 0.56 ± 0.10 | 1.27 ± 0.27 | 6.46 ± 4.1 |
| MRT (h) | 9.46 ± 0.61 | 10.1 ± 0.41 | 16.1 ± 2.3 |
| Tmax (h) | 0.38 ± 0.14 | 5.69 ± 4.13 | 11.5 ± 9.1 |
| Cmax (μg/mL) | 0.07 ± 0.04 | 0.13 ± 0.08 | 0.36 ± 0.11 |
| Tλ1/2 (h) | 31.1 ± 37.2 | 19.0 ± 18.5 | 28.9 ± 19.9 |
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; MRT = mean residence time; Tmax = time of peak plasma concentration; Tλ1/2 = terminal elimination half-life.