Table 35.

Pharmacokinetic parameters in rats after intravenous administration 5 mg/kg.

Parameter	Animal no.				Mean	SD
1	2	3	4
t1/2α (h)	0.586	0.155	0.109	0.131	0.245	0.228
t1/2β (h)	5.34	9.43	5.47	6.56	6.70	1.90
V (l/kg)	0.101	0.162	0.092	0.070	0.106	0.039
CL (l/(h kg))	0.053	0.117	0.075	0.073	0.080	0.027
AUC0–24 (mg h/L)	89.06	36.24	60.76	59.46	61.38	21.62
AUC0–∞ (mg h/L)	95.09	42.62	66.44	68.05	68.05	21.45

AUC = area under the concentration-time curve; SD = standard deviation; CL = clearance; t_1/2 = half life.