Table 36.

Pharmacokinetic parameters in rats after oral administration at 50 mg/kg.

Animal no.	1	2	3	4	Mean	SD
t1/2α (h)	1.35	0.67	1.78	1.55	1.33	0.48
t1/2β (h)	1.53	8.41	1.95	1.59	3.37	3.37
t1/2 ka	0.046	0.491	1.225	1.310	0.768	0.606
AUC0–8 (mg h/l)	2.41	1.52	0.55	0.93	1.35	0.81
AUC0–∞ (mg h/l)	2.67	1.86	0.62	1.05	1.55	0.91
Bioavailability (%)	0.39	0.27	0.09	0.15	0.23	0.13
Tmax (h)	3.00	2.00	2.00	4.00	2.75	0.96
Cmax (μg/L)	1000.2	611.3	192.3	895.2	674.8	361.2

Where t1/2ka is for the half-life of the absorption.

AUC = area under the concentration-time curve; C_max = peak plasma concentration; SD = standard deviation; T_max = time of peak plasma concentration; t_1/2β = elimination half-life.