Table 40.
Main pharmacokinetic parameters of swertiamarin after oral administration of 20 mg/kg to rats (n = 6, mean ± standard deviation).
| Parameters | Mean ± SD |
|---|---|
| t1/2z (h) | 1.104 ± 0.229 |
| Vz/F (L/kg) | 9.637 ± 4.322 |
| CLz/F (L/h/kg) | 5.638 ± 2.151 |
| AUC0–∞ (μg/L h) | 3593.7 ± 985.4 |
| MRT0–∞ (h) | 1.929 ± 0.364 |
| Tmax (h) | 0.945 ± 0.136 |
| Cmax (μg/L) | 1920.1 ± 947.0 |
AUC = area under the concentration-time curve; Cmax = peak plasma concentration; MRT = mean residence time; SD = standard deviation; Tmax = time of peak plasma concentration; CL/F = Apparent clearance; CL = Clearance; t1/2 = Half life.