Table 42.
Pharmacokinetic parameters of magnesium lithospermate B after intravenous administration in beagle dogs.
| Parameter | Dose/mg/kg |
||
|---|---|---|---|
| 3 | 6 | 12 | |
| C0 (/mg/L) | 24 ± 4 | 47 ± 12 | 107 ± 15 |
| AUC0-tn (/mg·min/L) | 109 ± 24 | 248 ± 55 | 582 ± 84 |
| AUC 0-∞ (/mg·min/L) | 109 ± 24 | 248 ± 55 | 583 ± 84 |
| MRT0-∞ (/min) | 16.3 ± 3.8 | 14.8 ± 2.9 | 14.0 ± 0.8 |
| k10 (/h) | 13.2 ± 2.1 | 11.6 ± 1.5 | 11.2 ± 1.3 |
| k12 (/h) | 5.2 ± 1.6 | 3.9 ± 2.2 | 3.1 ± 0.5 |
| k21 (/h) | 1.5 ± 0.5 | 1.4 ± 0.4 | 1.4 ± 0.3 |
| V/L (/kg) | 1.7 ± 0.5 | 1.6 ± 0.6 | 1.3 ± 0.3 |
| T1/2α (/min) | 2.2 ± 0.2 | 2.7 ± 0.5 | 2.9 ± 0.3 |
| T1/2β (/min) | 43 ± 9 | 42 ± 7 | 42 ± 10 |
| CL(/mL/min/kg) | 28 ± 5 | 26 ± 7 | 21 ± 3 |
n = 6. Mean ± SD.
AUC = area under the concentration-time curve; MRT = mean residence time; SD = standard deviation; C0 = initial plasma concentration; CL = clearance; t1/2 = half life.