Table 45.
Pharmacokinetic parameters after silibinin administration (100 mg/kg, intravenously and 500 mg/kg by mouth) for blood.
| Parameters | Silibinin (100 mg/kg i.v.) |
Silibinin (500 mg/kg p.o.) |
||
|---|---|---|---|---|
| Unconjugated | Total | Unconjugated | Total | |
| AUC (min mg/mL) | 5.5 ± 0.73 | 35.5 ± 5.9 | 0.26 ± 0.07 | 7.17 ± 1.42 |
| Cmax (μg/mL) | 256 ± 36 | 239 ± 19 | 8.5 ± 2.6 | 76 ± 15 |
| t1/2 (min) | 68 ± 7.2 | 105 ± 29 | 12.2 ± 1.8 | 77 ± 3.2 |
| Tmax | 0 | 8.2 ± 4.5 | 11 ± 1.8 | 30 ± 4.7 |
Data are expressed as mean ± standard error of the mean (n = 6).
AUC = area under the concentration time curve; Cmax = peak plasma concentration; i.v. = intravenous; p.o. = by mouth.