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Pharmacokinetic parameters after silibinin administration (100 mg/kg, intravenous and 500 mg/kg by mouth) for bile.
| Parameters | Unconjugated | Total |
|---|---|---|
| AUC (min mg/mL) | 11.1 ± 2.84 | 1202 ± 186 |
| Cmax (μg/mL) | 517 ± 85 | 7910 ± 2080 |
| t1/2 (min) | 33 ± 8.3 | 97 ± 28 |
| Tmax | 5.1 ± 1.0 | 50 ± 18 |
| AUC bile/AUC blood | 3.1 ± 0.95 | 30 ± 9.4 |
Data are expressed as mean ± standard error of the mean (n = 6).
AUC = area under the concentration time curve; Cmax = peak plasma concentration.
