Table 47.
Pharmacokinetic parameters after a single intravenous dose of 1.0, 2.0, and 4.0 mg/kg solamargine in rats (n = 5).
| Parameters | Mean ± SD |
||
|---|---|---|---|
| 1.0 mg/kg | 2.0 mg/kg | 4.0 mg/kg | |
| The plasma concentration at 5min (C5) (ng/mL) | 538.54 ± 278.79 | 1094.37 ± 694.87 | 2483.40 ± 272.89 |
| Cl (L/kg h) | 3.81 ± 0.68 | 4.10 ± 1.23 | 3.97 ± 0.44 |
| Vd (L/kg) | 20.16 ± 10.34 | 19.78 ± 12.55 | 15.68 ± 6.19 |
| t1/2 (h) | 3.54 ± 1.50 | 3.29 ± 1.52 | 2.76 ± 1.10 |
| AUC0–t (ng h/mL) | 242.41 ± 65.68 | 482.36 ± 138.07 | 947.74 ± 124.76 |
| AUC0–∞ (ng h/mL) | 270.50 ± 54.66 | 526.92 ± 161.72 | 1018.91 ± 117.26 |
AUC = area under the concentration time curve; SD = standard deviation; Cl = clearance; Vd = volume of distribution; t1/2 = half life.