Table 51.
Parameters | Estimated |
---|---|
A (μg/mL) | 71.9 ± 30.9 |
B (μg/mL) | 2.9 ± 0.5 |
α (L/min) | 0.14 ± 0.03 |
β (L/min) | 0.02 ± 0.004 |
t1/2α (min) | 5.0 ± 1.2 |
t1/2β (min) | 28.5 ± 4.7 |
AUC (min μg/mL) | 592.3 ± 124.7 |
Vss (mL/kg) | 277.7 ± 185.8 |
Cl (mL/min/kg) | 17.7 ± 4.5 |
Data expressed as mean ± standard deviation (n = 6); t1/2, α: distribution half-life; t1/2, β: elimination half-life.
AUC = area under the concentration-time curve; Cl = clearance; Vss = volume of distribution at steady state.